What is Spiriva? Spiriva Handihaler (tiotropium bromide inhalation powder) is an anticholinergic bronchodilator used in the treatment of COPD, emphysema and chrnoic bronchitis. What are the side effects of Spiriva? The most common side effects of Spiriva are dry mouth and constipation. Other side effects include eye pain and trouble urinating. If you’ve got COPD…